Although there are several individual measurements of environmental AMR across water bodies and soil, we lack a consistent record of local AMR over time. In turn, this constrains the development of an effective response. The recent pandemic has underlined the importance of tracking environmental bacterial reservoirs, establishing a lab-environment-clinic axis and developing databases that will enable advance warning mechanisms. We hope to build on our basic science observations in exploring mechanisms of tolerance and resistance, while also foraying into public health problems and drug design.